Highlights • Postnatal and adult murine SVZ precursor cells express Cx3cr1 and bind fractalkine • Fractalkine enhances OPC and oligodendrocyte formation from SVZ NPCs • Inhibition of fractalkine signaling reduces SVZ NPC and OPC oligodendrogenesis • Fractalkine signaling regulates oligodendrogenesis in ex vivo cerebellar slices Summary Neural and oligodendrocyte precursor cells (NPCs and OPCs) in the subventricular zone (SVZ) of the brain contribute to oligodendrogenesis throughout life, in...
