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Background: Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in overexpression of cyclin D1 (CCND1). Rarely, MCL results from translocations involving other genes (ie, IGK, IGL, CCND2, CCND3, or CCNE). CCND1 immunohistochemistry and t(11;14) fluorescence in situ hybridization (FISH) may fail to detect cases with these alternative translocations.
Angioedema in a 61-year-old Patient with Underlying Lymphoproliferative Disorder To the editor A 61-year-old female presented to the emergency department for sudden tongue swelling with difficulty talking and swallowing. She received epinephrine and was admitted to the intensive care unit (ICU). Swelling resolved within a few hours after treatment with diphenhydramine and steroids. The patient did not require intubation.
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