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Prithwish Goswami

As seen in: MDPI, Cell Reports Physical Science
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Articles by Prithwish Goswami

p97 Inhibitors Possessing Antiviral Activity Against SARS-CoV-2 and Low Cytotoxicity

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By Rui Ding, Tiffany Edwards, Prithwish Goswami, Daniel Wilson
| MDPI
1. Introduction p97, also known as valosin-containing protein (VCP), belongs to the AAA+ (ATPase associated with various cellular activities) ATPase family []. p97 is a homohexamer and each subunit contains an N-domain, two ATPase domains (D1 and D2), and a short unstructured C-terminal tail []. The N-domain is flexible and can therefore engage in interactions with varied adaptor proteins, leading to subcellular localization of p97 and the recognition of different substrates [].
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Pinacolborane-assisted superacid organocatalysis enabled direct access to cytotoxic alkyl N-Cbz amines

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By Da Eun Lee, You Kyoung Chung, Woo Hee Kim, Prithwish Goswami
| Cell Reports Physical Science Verified
Highlights • Pinacolborane-assisted superacid catalysis toward alkyl N-Cbz amines using carbonyls • Robust catalysis achieves a general substrate scope with reliable scalability • The formation of protonated pinacolborane enables reductive amination with carbamates • Cytotoxicity against human cancer cell lines is demonstrated Summary α-Secondary alkyl amines are structural motifs frequently encountered in a wide variety of natural products and pharmaceuticals.
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