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Articles by Qi Han
Mechanistic studies of tyrosine phosphatase SHP2 in hypoxic environment to promote angiogenesis in HCC by modulating the ROS/Src pathway
Abstract The progression of hepatocellular carcinoma (HCC) was highly dependent on pathological angiogenesis, with tumor-associated macrophages (TAMs) serving as key mediators regulating angiogenesis within the tumor microenvironment. The role of protein tyrosine phosphatase 2 (SHP2), a multi-signaling pathway regulator containing an SH2 domain, in TAM-mediated angiogenesis remained unclear.
Enhancing tyrosine kinase inhibitor sensitivity by restoring IKAROS activity on GLUT1 expression and glycolysis in Philadelphia chromosome-positive acute lymphoblastic leukemia | Leukemia
Abstract Many patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) are still less sensitive to tyrosine kinase inhibitors (TKIs). Ph+ ALL shows a high incidence of IKZF1 deletions. Casein kinase II (CK2)-mediated hyperphosphorylation of IKZF1, encoding protein IKAROS, contributes to its dysfunction, and CK2 inhibitor, CX-4945, restores IKAROS function in high-risk ALL.
TMEM150A overexpression was associated with poor prognosis and cancer progression in glioma verified by comprehensive analysis and cell experiments - Scientific Reports
Abstract Transmembrane (TMEM) proteins play a pivotal role in cancer progression, with TMEM150A specifically implicated in tumorigenesis. Despite its association with cancer, the precise role of TMEM150A in glioma remains underexplored. The expression of TMEM150A in glioma and its correlation with prognosis and the immune microenvironment were systematically analyzed. Prognostic models were developed using nomograms to establish the relationship between TMEM150A expression and patient survival.
Snowflake-Like Cu2O-Pt Nanocluster Mediated Fenton Photothermal and Chemodynamic for Antibiotic Wound Healing Therapy
Snowflake-Like Cu2O-Pt Nanocluster Mediated Fenton Photothermal and Chemodynamic for Antibiotic Wound Healing Therapy TheFenton reaction serves as the fundamental mechanism behind chemodynamic therapy (CDT), wherein highly reactive hydroxyl radicals (•OH) are produced to efficiently induce bacterial cell death.
Instantaneous self-recovery and ultra-low detection limit hydrogel electronic sensor for temporomandibular disorders intelligent diagnosis - Nature Communications
Abstract Temporomandibular disorders (TMD) intelligent diagnosis promises to elevate clinical efficiency and facilitate timely TMD management for patients. However, development of TMD intelligent diagnostic tools with high accuracy and sensitivity presents challenges, particularly in sensing minute deformations and ensuring rapid self-recovery. Here we report a biocompatible hydrogel electronic sensor with instantaneous self-recovery (within 2.1 s) and ultra-low detection limit (0.005% strain).
Self-assembled two-dimensional metal-organic framework membrane as nanofluidic osmotic power generator
Self-assembled two-dimensional metal-organic framework membrane as nanofluidic osmotic power generator Metal-organic framework (MOF) membranes with high ion selectivity and permeation rates have emerged as excellent platforms for high-performance osmotic energy harvesting. However, only a few MOFs have been successfully fabricated as selective ion transport membranes for high-performance osmotic energy generation due to the challenge of high-quality MOF membrane fabrication.
Effect of Natural Organic Matter (NOM) on the Removal Efficiency of Hg(II) by MoS2: Dependence on the Hg/MoS2 Ratio and NOM Properties
Effect of Natural Organic Matter (NOM) on the Removal Efficiency of Hg(II) by MoS2: Dependence on the Hg/MoS2 Ratio and NOM Properties Mercury (Hg) contamination in groundwater poses significant environmental and health risks, necessitating effective remediation strategies. Recently, molybdenum disulfide (MoS2) nanosheets have emerged as a promising nanomaterial for the remediation of Hg-associated contaminated groundwater.
Piezoelectric Materials for Neuroregeneration: A Review
Piezoelectric Materials for Neuroregeneration: A Review The purpose of nerve regeneration via tissue engineering strategy is to create a microenvironment that mimics natural nerve growth for achieving the functional recovery. Biomaterial scaffolds offer a promising option for the clinical treatment of large nerve gaps due to the rapid advancement of materials science and regenerative medicine.
Emerging investigator series: Correlating of Phase Composition and Geometric Structure to the Colloidal Stability of 2D MoS2 Nanomaterials
Emerging investigator series: Correlating of Phase Composition and Geometric Structure to the Colloidal Stability of 2D MoS2 Nanomaterials Bei Liu, Zixin Han, Qi Han, Yufei Shu, Mengxia Wang, Li Wang, Zhongying Wang and Joel A. Pedersen Abstract Aggregation significantly influences the transport, transformation and bioavailability of engineered nanomaterials in aquatic environments.
Hydroxyl-rich surface of Ti3C2Tx for metal sulfides as high performance electrode materials for sodium/lithium storage
Hydroxyl-rich surface of Ti3C2Tx for metal sulfides as high performance electrode materials for sodium/lithium storage Three kinds of Ti3C2Tx modified metal sulfides composites have been prepared via a universal one-step strategy. First, three Ti3C2Tx MXene with different surface F/O ratios and layer distances supported MoS3 composites are synthesized.
Inorganic Salt Reinforced Zn2+-conducting Solid-state Electrolyte for Ultra-stable Zn Metal Battery
Inorganic Salt Reinforced Zn2+-conducting Solid-state Electrolyte for Ultra-stable Zn Metal Battery The rapid development of flexible and wearable electronics calls for advanced batteries with high safety, long cycling stability, and low cost. Aqueous Zn metal batteries (ZMBs) are one of the most promising candidates. The main challenges are the water-induced parasitic reactions (corrosion and passivation) and dendrites-driven battery failure in traditional liquid electrolyte.
Durable, Flexible Self-standing Hydrogel Electrolyte Enabling High-safety Rechargeable Solid-state Zinc Metal Battery
The boom of flexible and wearable electronic devices boosts the development of flexible batteries with high safety and stability. However, traditional lithium-ion liquid batteries dominating in portable energy storage devices are significantly restricted by their intrinsic safety hazards.
Circular RNA PVT1 expression and its roles in acute lymphoblastic leukemia
This work is supported in part by National Natural Science Foundation of China (81770172, 81602300); Jiangsu Provincial Natural Science Foundation-Youth Foundation (BK20170699, BK20160139); The Key Research & Technology Projects in Jiangsu Province (BE2017747); Milstein Medical Asian American Partnership (MMAAP) Foundation Research Project Award in Hematology (2017).
Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis
To determine whether CMA activity is increased in breast tumors or the related metastatic carcinoma in lymph nodes, we assessed LAMP2A expression in 166 breast cancer specimens and 21 normal breast epithelium specimens by immunohistochemical staining. LAMP2A protein expression showed a statistically significant difference between malignant breast cancer tissues, metastatic carcinoma of the lymph nodes and normal tissues.
Bailey Willis’ Geological Research and His Influence in China (維理士對中國地質的研究及其影響)
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