Abstract Patients with chronic obstructive pulmonary disease (COPD) are susceptible to Aspergillus-related disease, but associated host-response alterations remain incompletely understood. We conducted an exploratory study in male C57BL/6 mice (n = 3/group) assigned to control, COPD-like lung injury, acute Aspergillus fumigatus challenge, or combined challenge. COPD-like lung injury was induced by cigarette-smoke exposure and intranasal lipopolysaccharide administration, whereas acute A.
