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Abstract ALKBH5 is a key determinant of oocyte quality by regulating N6-methyladenosine (m6A) to maintain maternal RNA stability in oocytes. However, the role of ALKBH5 in oocytes other than m6A has not been reported. Here, we document that ALKBH5 is expressed and localized to spindle during mouse oocyte meiotic maturation. The abnormal spindle in Alkbh5-/- oocytes can be both partially restored by the ectopic expression of exogenous wild-type Alkbh5 and enzymatically dead Alkbh5-H205A.
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