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Abstract Tissue stiffening is a predominant malignant physical alteration in cancer progression, yet its effect on specific immune subsets within the tumor microenvironment is not well defined. Here we show that elevated tissue stiffness subverts tumor-infiltrating type 1 helper T (TH1) cells to drive immunosuppression in pancreatic cancer.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
