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Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. Article PubMed Google Scholar Villanueva A. Hepatocellular Carcinoma. N Engl J Med. 2019;380(15):1450–62. Article CAS PubMed Google Scholar Vogel A, Meyer T, Sapisochin G, Salem R, Saborowski A. Hepatocellular carcinoma. Lancet (London, England). 2022;400(10360):1345–62.
1 INTRODUCTION Primary liver cancer is one of the most common malignant tumors in the world. According to the global cancer statistics, liver cancer is the sixth most common malignant tumor and the third leading cause of cancer death worldwide in 2020.1 Hepatocellular carcinoma (HCC) is the most important tissue type, accounting for about 75%–85% of the primary liver cancer.
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