Enantioselective Cross-Dehydrogenative Coupling Enabled by Organocatalysis Oxidative cross-dehydrogenative coupling (CDC) reactions offer an attractive fashion for the direct formation of C-C and C-X (X = heteroatom) bonds because of no need of prefunctionalization of substrates. Due to the atom-economical nature, these reactions are considered environmentally friendly. While nonasymmetric CDC reactions have been extensively explored, asymmetric versions are still underdeveloped.