Abstract Asthma is a chronic inflammatory airway disease. Diet may influence asthma through oxidative stress, inflammation, and gut–lung axis interactions. Evidence on the PURE Healthy Diet Score (PHDS) remains scarce. This study investigated PHDS adherence in relation to asthma odds, pulmonary function, asthma control, biomarkers, and quality of life in adults. This age‑matched case–control study included 200 adults with physician‑diagnosed asthma and 200 healthy controls.