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Background: Treatment paradigms in lung NET have conventionally relied on therapies such as chemotherapy, radiotherapy and somatostatin analogs (SSA) although evidence from randomized clinical trials remains limited.
Background: In the CLARINET trial, lanreotide (LAN) 120 mg resulted in a 53% reduction in the risk of death or disease progression, compared with placebo, in GI-NET patients. Several studies have identified diabetic patients (pts) as having increased risk for the development of cancer and have associated metformin (MET) treatment with a decrease of cancer risk.
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