Introduction The past two decades have witnessed a substantial rise in the incidence and severity of Clostridium difficile infection (CDI)1 with CDI surpassing methicillin resistant Staphylococcus aureus as the leading cause of nosocomial infection.2 The incidence has increased in hospital and community settings, and a hypervirulent strain (B1/NAP1/027) associated with increased morbidity and mortality has emerged.1, 3 Inflammatory bowel disease (IBD) is an independent risk factor for CDI...