By Rachael Harsch, Jonny Jackson, Feng Gu, Ph.D., Gina Dell, and Jeffrey Cassel Repeated caustic sanitization can reduce Protein A ligand performance, making long-term consistency a key consideration in capture operations. Testing across 100 harvest purification cycles evaluated how a membrane-based GORE® Protein Capture Device responded to sodium hydroxide sanitization every 10 cycles. Results showed stable pressure, consistent elution volumes, and yields above 90% through cycle 90.
