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Loading metrics Open Access Peer-reviewed Research Article Hyesuk Seo , Rahul M. Nandre , Jerome Nietfeld, Zhenhai Chen, Qiangde Duan, Weiping Zhang Hyesuk Seo, Rahul M. Nandre, Jerome Nietfeld, Zhenhai Chen, Qiangde Duan, Weiping Zhang Published: May 1, 2019 https://doi.org/10.1371/journal.pone.0216076 Figures Abstract Antibodies that block the adherence of enterotoxigenic Escherichia coli (ETEC) to host intestinal epithelial cells are protective.
Enterotoxigenic Escherichia coli (ETEC) strains are a leading cause of children's diarrhea and travelers' diarrhea. Vaccines inducing antibodies to broadly inhibit bacterial adherence and to neutralize toxin enterotoxicity are expected to be effective against ETEC-associated diarrhea. 6×His-tagged adhesin-toxoid fusion proteins were shown to induce neutralizing antibodies to several adhesins and LT and STa toxins (X. Ruan, D. A. Sack, W.
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