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Correction to: Nature Communications https://doi.org/10.1038/s41467-026-75835-7, published online 27 July 2026 In this article, the single line connecting the “1” and “2” labels in the Figure 1 (ADPR) structure was missing. The figure should have appeared as shown below. The original article has been corrected.
Abstract Enzymatically active macrodomains of (+)ss-RNA viruses mediate immune evasion by countering ADP-ribosylation and are therefore promising druggable targets. Here we report testing of ADP / ADP-ribose analogues for their ability to inhibit Mac1 of SARS-CoV-2, measurement of the affinity of active compounds and characterization of their binding mode by cocrystallization, uncovering critical molecular determinants of protein-ligand interaction.
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