Over the last years, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) has shown a dramatic increase relative to other head and neck cancers, with a substantial proportion of OPSCC being linked to human papillomavirus (HPV) infections.1 HPV positive OPSCC is biologically and clinically different from HPV negative OPSCC, which is often related to alcohol and tobacco consumption. HPV positive OPSCC has been shown to have superior response to radiochemotherapy.
