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Rebecka Jornsten

As seen in: Nature, BioRxiv
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Articles by Rebecka Jornsten

Reconstructing the single-cell spatiotemporal dynamics of glioblastoma invasion

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By Hitesh Bhagavanbhai Mangukiya, Madeleine Skeppas, Irem Uppman, Soumi Kundu, Maria Berglund, Adam Malik Verified, Cecilia Krona, Rebecka Jornsten, Sven Nelander, André Lasses Armatowski, Linnea Hallin, Filippa Kruse, Clara Nordquist
| Nature Verified
Abstract Glioblastoma invasion into healthy brain tissue remains a major barrier to effective treatment, but the dynamic single-cell behaviors underlying this process remain difficult to measure across patient models. Here, we introduce GlioTrace, an ex vivo imaging and computational framework for real-time tracking of glioblastoma invasion in patient-derived xenograft brain slices.
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Data-driven representations using deep network-coherent methylation autoencoders to identify robust disease and risk factor signatures

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By Sanjiv K. Dwivedi, Mika Gustafsson, David Martinez-Enguita, Rebecka Jornsten
| BioRxiv
New Results doi: https://doi.org/10.1101/2023.03.07.531501 Abstract Data analysis in systems medicine often employs knowledge-driven approaches, which leverage prior biological insights to guide and inform the study of large omic sets. However, the current state of knowledge in biology is still partial and biased. For example, cancer-associated genes are overrepresented in protein interaction networks. As a result, these approaches may fail to capture novel or unexpected phenomena.
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