Footnotes Ren Hou has nothing to disclose. Renliang Huang has nothing to disclose. Yanling Zhou has nothing to disclose. Dan Lin has nothing to disclose. Jing Xu has nothing to disclose. Liuqing Yang has nothing to disclose. Xiaolan Wei has nothing to disclose. Zhuoming Xie has nothing to disclose. Qiaomiao Zhou reports grant from the Major Science and Technology Program of Hainan Province (Grant No.ZDKJ2021037) , and the Project of Hainan Province Clinical Medical Center (QWYH202175).