Figure 1 Diagram showing the adipocentric view of diabetes pathogenesis. In excessive energy supply, the expandability of adipose tissue (AT) is exceeded, and AT dysfunction and inflammation occur. The impaired AT sends lipid (free fatty acids) and non-lipid (adipokines, chemokines and EVs) detrimental mediators to the pancreas, leading to increased lipid availability, pancreatic lipid accumulation and inflammation, lipotoxicity, impaired insulin secretion and islet destruction.