Skip To Main Content
Renliang Yang on Muck Rack

Renliang Yang

Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile
Back to Renliang Yang’s profile

Articles by Renliang Yang

Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity

|
By Renliang Yang, Nanyang Technological, Poulomi Das, Khac Huy Ngo
| Royal Society of Chemistry Verified
Cyclization of a G4-specific peptide enhances its stability and G-quadruplex binding affinity† G-quadruplexes (G4) are non-canonical nucleic acid structures with important implications in biology. Based on an α-helical fragment of the RHAU helicase that displays high specificity for parallel-stranded G-quadrplexes, herein we demonstrate its head-to-tail cyclization by a high-efficiency ligase.
Open in Who Shared Issue with article?

Engineering a Catalytically Efficient Recombinant Protein Ligase

|
By James P. Tam, Renliang Yang, Julien Lescar
| American Chemical Society
Breaking and forming peptidyl bonds are fundamental biochemical reactions in protein chemistry. Unlike proteases that are abundantly available, fast-acting ligases are rare. OaAEP1 is an enzyme isolated from the cyclotide-producing plant oldenlandia affinis that displayed weak peptide cyclase activity, despite having a similar structural fold with other asparaginyl endopeptidases (AEP). Here we report the first atomic structure of OaAEP1, at a resolution of 2.56 Å, in its preactivation form.
Open in Who Shared Issue with article?
Show More