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Abstract Arg-Gly-Asp peptide (RGD) binds to αvβ3 integrins, which are involved in the development of new vessels, necessary for tumor growth. Several RGD-based PET radiopharmaceuticals have been developed to visualize integrin αvβ3 expression. Differences between O-(2-[18F]-fluoroethyl)-L-tyrosine ([18F]FET) and integrin-targeting radiopharmaceuticals in patients with brain tumors have not been evaluated so far.
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