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Abstract TDP-43 is a conserved RNA/DNA-binding protein infamous for its pathological roles in numerous human neurodegenerative diseases. However, TDP-43 is expressed in diverse cell types and its evolved biological functions are unclear. We show that Drosophila TDP-43 homolog (TBPH) and its retrocopy (Cocoon) are expressed in prophase I of male meiosis and promote regulated expression of abundant double-stranded RNAs (dsRNAs) in spermatocyte nuclei.
Featured ArticleResearch Articles, Neurobiology of Disease Aaron Held, Paxton Major, Asli Sahin, Robert A. Reenan, Diane Lipscombe and Kristi A. Wharton Journal of Neuroscience 20 March 2019, 39 (12) 2347-2364; DOI: https://doi.org/10.1523/JNEUROSCI.1771-18.2019 Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease for which the origin and underlying cellular defects are not fully understood.
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