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Articles by Robert Lins
Price increase negotiations to address drug shortages in South Korea’s national health insurance
1 Introduction Pharmaceuticals are public goods essential for preventing and treating diseases, necessitating a national system for appropriate supply according to demand (Phuong et al., 2019). When supply falls short of demand, resulting in a drug shortage, patients may experience exacerbated conditions and be exposed to side effects due to inappropriate substitute medications (Tucker et al., 2020).
Diagnostics and treatments of COVID-19: two-year update to a living systematic review of economic evaluations
1 Introduction The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease (COVID-19) pandemic placed healthcare systems and wider economies under massive strain in 2020 and 2021. Decisions about diagnostic tests and treatments for the disease were made rapidly, forgoing traditional, rigorous health technology assessments (HTAs) that healthcare interventions are subjected to in many countries.
The efficacy and safety of condoliase for lumbar disc herniation: a systematic review and meta-analysis
Zeling Huang† Bo Xu† Yujiang Liu† Hua Chen Xuefeng Cai Long Zhang Xiaofeng Shen* Yuwei Li* Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu, China Background: Chemonucleolysis is a minimally invasive treatment of lumbar disc herniation (LDH). However, the low specificity of the enzyme and the existence of serious adverse events limit the application of chemonucleolysis.
Sputum induction for assessment of biomarkers in early development of new drugs for respiratory disease in a proof of concept setting
AbstractBackground: Induced sputum is the best available noninvasive assessment of bronchial inflammation in asthma. However, reproducibility and validity in normal subjects have limited its use for proof of concept studies. Therefore we studied the characteristics of healthy volunteers (HV) and asthma patients (AP) in sputum induction (SI).Method: HV and AP recruited in a phase 1 unit for participating in respiratory early phase studies, with SI in the baseline screening were included.
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