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Articles by Robert Pickering
A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability
Abstract cGAS is the primary innate immune DNA sensor. On binding DNA, cGAS generates cGAMP, ultimately driving inflammation. Although normally silenced on self-DNA, genotoxic stress can activate cGAS, proposed to be mediated by micronuclei, chromosome bridges and DNA:RNA hybrids. However, mechanistically, this is poorly understood due to a lack of sensitive and selective single-cell cGAS activation assays.
Let Us Have Peace: A Catalogue of Indian Peace Medals at the American Numismatic Society
Advanced search Plains Anthropologist Latest Articles Submit an article Journal homepage Full Article Figures & data References Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/00320447.2026.2676909?needAccess=true Click to increase image sizeClick to decrease image size Log in via your institution Access through your institution Log in to Taylor & Francis Online Log in Shibboleth Log in to Taylor & Francis Online Forgot password?
It's Too Late to Become a Technological Leader. Just Become a Shoveller!
Taking as an example the cloud industry, we help break down the different types of services and innovations that create value in technological markets where large leaders have taken a lead. The new technological “El Dorados” are a great opportunity for many. From quantum computing to regenerative language, large firms like Google, Microsoft, and Amazon are taking a leading role and experiencing significant growth. However, similar to what happened during the gold rush, not everyone will find gold.
Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages
Open Access Anna M. Gram, John A. Wright, Robert J. Pickering, Nathaniel L. Lam, Lee M. Booty, Steve J. Webster and Clare E. Bryant J Immunol February 1, 2021, 206 (3) 631-640; DOI: https://doi.org/10.4049/jimmunol.2000382 Key Points Salmonella infection leads to NAIP/NLRC4 and NLRP3 inflammasome activation. Flagellin activates the NAIP/NLRC4 and NLRP3 inflammasome in human macrophages. Flagellin mediates NLRP3 activation in a ROS- and/or cathepsin-dependent manner.
Salmonella Flagellin Activates NAIP/NLRC4 and Canonical NLRP3 Inflammasomes in Human Macrophages
Open Access Anna M. Gram, John A. Wright, Robert J. Pickering, Nathaniel L. Lam, Lee M. Booty, Steve J. Webster and Clare E. Bryant J Immunol December 30, 2020, ji2000382; DOI: https://doi.org/10.4049/jimmunol.2000382 Key Points Salmonella infection leads to NAIP/NLRC4 and NLRP3 inflammasome activation. Flagellin activates the NAIP/NLRC4 and NLRP3 inflammasome in human macrophages. Flagellin mediates NLRP3 activation in a ROS- and/or cathepsin-dependent manner.
Macrophage reprogramming for therapy
Summary Dysfunction of the immune system underlies a plethora of human diseases, requiring the development of immunomodulatory therapeutic intervention. To date, most strategies employed have been focusing on the modification of T lymphocytes, and although remarkable improvement has been obtained, results often fall short of the intended outcome. Recent cutting‐edge technologies have highlighted macrophages as potential targets for disease control.
NLR in eXile: Emerging roles of NLRX1 in immunity and human disease
Summary NLRX1 is a member of the NOD‐like receptor family, a set of pattern recognition receptors associated with innate immunity. Interestingly, NLRX1 exists in somewhat of an exile from its NLR counterparts with unique features that mediate atypical functions compared with traditional NOD‐like receptors (NLRs). Aside from a mitochondrial targeting sequence, the N‐terminal region is yet to be characterized.
Preventing pores and inflammation
PerspectiveImmunology Robert J. Pickering, Clare E. Bryant Departments of Medicine and Veterinary Medicine, University of Cambridge, Cambridge, UK. Email: ceb27{at}cam.ac.uk See allHide authors and affiliations Science 25 Sep 2020: Vol. 369, Issue 6511, pp. 1564-1565 DOI: 10.1126/science.abe0917 Summary Inflammation is a tightly regulated process that is essential for host protection against infections.
Coronavirus rates
I would challenge everyone to do a little critical thinking. I’m not trying to make light of any deaths, these are just the facts. According to Texas Health and Human Services the Texas death rate is 0.0088%. As horrible as that number is, I’m worried about the living souls. Forcing them to suffer the trials of another shutdown is far worse. kA 4=2DDlQAaQmp44@C5:?8 E@ E96 w2CC:D r@F?EJ !F3=:4 w62=E9 s6A2CE>6?E be` 562E9D @44FCC65 :?
Beyond Foundations of F# - Asynchronous Workflows
Mar 23, 2008 11 min read Write for InfoQ Join a community of experts. Increase your visibility. Grow your career.Learn more My previous article for InfoQ, "Beyond Foundations of F# - Workflows", introduced new language feature workflows. This article will look at an interesting use of the workflow feature called asynchronous workflows, which are aimed at simplifying .NET's asynchronous programming model.
Beyond Foundations of F# - Workflows
Creating a Workflow Workflows are composed of two parts; the code the users defines which makes up the instances of the workflow and the library component that defines what the workflow does. Let's take a look at very simple example of a workflow: This article builds on my previous article for InfoQ, "Beyond Foundations of F# - Active Patterns", introducing another new language feature - workflows.
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