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Objective: Sociodemographic, lifestyle and medical variables influence total testosterone (T) and sex hormonebinding globulin (SHBG) concentrations. The relationship between these factors and free T remains unclear. We examined 21 sociodemographic, lifestyle and medical predictors influencing calculated free T (cFT) in community-dwelling men across ages. Design: Cross-sectional analysis in 20,631 participants in the Androgens in Men Study.
To the Editor Five-years ago, we published the first Mendelian randomization study1 of the cardiometabolic and mortality risk related to testosterone and concluded that reported observational associations might largely result from residual confounding or reverse causation.
Background Fibroblast growth factor 23 (FGF23) is emerging as a novel biomarker of bone metabolism, chronic kidney disease, and cardiovascular disease (CVD). However, its clinical correlates and potential predictive role in a community‐based setting are incompletely understood.
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