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Articles by Robin Pedersen
Brain cognition gaps reveal associations with dopamine and factors related to brain health through artificial intelligence prediction of functional connectome
eLife Assessment This multimodal neuroimaging study leverages fMRI, PET, and deep learning to predict memory performance. The authors introduce the brain cognition gap to link these different imaging modalities to cognition and evaluate their results in two independent cohorts. The results are solid and provide an important contribution to the literature and will be of interest to neuroscientists working at the interface of cognition, neuroimaging.
Høringsuttalelse Harstad Dokkhall
Debattinnlegg Høringsuttalelse Detaljregulering for Harstad dokkhall, Fjordgata (PlanID 832) Saksnr. 23/17700 Til Harstad kommune Jeg ønsker med dette å avgi høringsuttalelse til detaljreguleringen for Harstad dokkhall, Fjordgata (PlanID 832). Innledningsvis vil jeg understreke at dette ikke er en uttalelse mot HSI, verftsindustrien eller behovet for en ny dokkhall.
Granerud slo tilbake: – Viser oss hva han kan
Halvor Egner Granerud leverte et solid hopp på 135,5 meter og ble nummer sju i kvalifiseringen til det siste rennet i hoppuka. Halvor Egner Granerud i aksjon under hoppuka. Foto: Matthias Schrader / AP / NTB Årets utgave av den tysk-østerrikske hoppuka avsluttes i Bischofshofen tirsdag. Mandag var det kvalifisering, og der slo Granerud til med et fint svev. – Han har strevd veldig i mange omganger. Her slår han tilbake og viser oss hva han kan, sa Viaplay-ekspert Anders Jacobsen.
Two long-axis dimensions of hippocampal-cortical integration support memory function across the adult lifespan
eLife Assessment This fundamental work demonstrates the importance of considering overlapping modes of functional organization (i.e. gradients) in the hippocampus, showing associations with aging, dopaminergic receptor distribution and episodic memory. The evidence supporting the conclusions is convincing, although not all analyses were performed in a replication sample. The work will be of broad interest to basic and clinical neuroscientists.
Brain-Cognitive Gaps in relation to Dopamine and Health-related Factors: Insights from AI-Driven Functional Connectome Predictions
Abstract A key question in human neuroscience is to understand how individual differences in brain function are related to cognitive differences. However, the optimal condition of brain function to study between-person differences in cognition remains unclear. Additionally, there is a lack of objective biomarkers to accurately predict cognitive function, with brain age emerging as a potential candidate.
Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging
Abstract Age-related alterations in cortico-striatal function have been highlighted as an important determinant of declines in flexible, higher-order, cognition in older age. However, the mechanisms underlying such alterations remain poorly understood. Computational accounts propose age-related dopaminergic decreases to impoverish neural gain control, possibly contributing to reduced specificity of cortico-striatal circuits, that are modulated by dopamine, in older age.
Dedifferentiation of caudate-cortical connectivity is linked to reduced D1 dopamine receptor availability and poorer memory function in aging
Abstract Decreasing integrity of striato-cortical circuits has been highlighted as an important determinant of declines in flexible, higher-order cognition in older age. Here, leveraging multi-modal (fMRI, PET) neuroimaging data from a large adult lifespan sample, we demonstrate older age to be associated with less specific functional coupling between the caudate and cortical association networks.
Dopamine D1-Receptor Organization Contributes to Functional Brain Architecture
architecture dopamine functional connectivity gradients organization Significance Statement Dopamine D1-receptors, the most abundantly expressed dopamine receptor type, expresses a high correspondence to the large-scale functional organization of the cortex. Differences in receptor density between unimodal and transmodal regions were related to the shape of the principal gradient of functional connectivity, contributing to greater differentiation of somatomotor and default mode networks.
Longitudinal monitoring of the mouse brain reveals heterogenous network trajectories during aging - Communications Biology
Abstract The human aging brain is characterized by changes in network efficiency that are currently best captured through longitudinal resting-state functional MRI (rs-fMRI). These studies however are challenging due to the long human lifespan. Here we show that the mouse animal model with a much shorter lifespan allows us to follow the functional network organization over most of the animal’s adult lifetime.
Dopamine D1-receptor Organization Contributes to Functional Brain Architecture
Dopamine D1-receptor Organization Contributes to Functional Brain Architecture Robin Pedersen, Jarkko Johansson, Kristin Nordin, Anna Rieckmann, Anders Wåhlin, Lars Nyberg, Lars Bäckman, Alireza Salami Journal of Neuroscience 1 February 2024, e0621232024; DOI: 10.1523/JNEUROSCI.0621-23.2024
Two long-axis dimensions of hippocampal cortical integration support memory function across the adult lifespan
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Dopamine D1-receptor Organization Contributes to Functional Brain Architecture
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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