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Rodney J Y

As seen in: Oxford Academic, Frontiers
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Articles by Rodney J Y

Long-acting Injectable Containing Lopinavir Eliminates Reliance on Ritonavir Pharmacokinetic Enhancement

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By Johns Hopkins, Bender Ignacio, Rodney J Y
| Oxford Academic Verified
High-extraction protease inhibitors (e.g., for HIV and COVID-19) typically require ritonavir to enhance bioavailability by overcoming first-pass metabolism. However, in the long-acting subcutaneous injectable dosage form TLC-ART 101, lopinavir persisted in plasma for 57 days, while ritonavir was detectable for only 3–7 days.
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Viral dissemination and immune activation modulate antiretroviral drug levels in lymph nodes of SIV-infected rhesus macaques

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By Rodney J Y, Di Mascio
| Frontiers
Introduction The two most commonly used nucleos(t)ide reverse transcriptase inhibitors (NRTIs), tenofovir (TFV) and emtricitabine (FTC), in antiretroviral (ARV) therapy (ART) for HIV-infection in humans are also the ones, but only in combination with one another, approved for daily use as pre-exposure prophylaxis (PrEP) of HIV prevention strategy. In HIV-infection in humans and SIV-infection of rhesus macaques (RMs), lymphoid tissues are a major site of viral production and storage (1).
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