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Rodney Tatum

As seen in: Nature, Wiley Online Library
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Articles by Rodney Tatum

Small molecules targeting ARF1 interaction with C9orf72:SMCR8:WDR41 complexes suppress its overactivation implicated in ALS/FTD

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By Emma Dixon Verified, Fereshteh Azimian, Rodney Tatum, Yan-Hua Chen, Qun Lu, Angelina Joby Chacko, Christi Boykin
| Nature Verified
Abstract The hexanucleotide repeat expansion in C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD). The C9orf72 protein forms a complex with SMCR8 and WDR41 (CSW), which functions as a GTPase-activating protein (GAP) regulating ARF1 and RAB small GTPases.
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Colonic crypt stem cell functions are controlled by tight junction protein claudin‐7 through Notch/Hippo signaling

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By Amna Naser, Tiaosi Xing, Qun Lu, Rodney Tatum
| Wiley Online Library Verified
INTRODUCTION Colorectal cancer (CRC) progression is marked by increased proliferation of cancerous stem cells, progressing from an adenomatous polyp to adenocarcinoma.1, 2 Claudin-7-deficient mice exhibit intestinal hyperplasia suggesting a role for claudin-7 in controlling proliferation within the intestine.3−5 Our group previously identified a novel role for claudin-7 in regulating intestinal epithelial stem cell (IESC) survival, self-renewal, and differentiation in the small intestine...
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