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1 Introduction Cancer cachexia is a complex condition characterized by significant muscle loss [1, 2], affecting up to 80% [3] of patients with advanced-stage cancer, particularly those with gastrointestinal (GI) and lung cancers [4, 5]. Among cancers of the GI tract, colon cancer (CC) is the most prevalent [5], with approximately 30% of patients exhibiting cachexia at diagnosis [4, 5].
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