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Abstract Hantaviruses are rodent-borne pathogens that cause severe human disease for which no approved therapeutics are available. New World hantaviruses, including Andes virus (ANDV), use the cell-surface receptor protocadherin-1 (PCDH1) to enter host cells1. However, the structural basis of this interaction remains unclear. Here we describe the structure of PCDH1 bound to the ANDV spike at near-atomic resolution.
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Ward BJH, Prasai K, Schaal DL, Wang J, Scott RS (2023) A distinct isoform of lymphoid enhancer binding factor 1 (LEF1) epigenetically restricts EBV reactivation to maintain viral latency. PLoS Pathog 19(12): e1011873. https://doi.org/10.1371/journal.ppat.1011873 Editor: Paul M.
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Cellular Response to Infection | Spotlight Malgorzata Bienkowska-Haba, Wioleta Luszczek, Katarzyna Zwolinska, Rona S. Scott, Martin Sapp Lawrence Banks, Editor DOI: 10.1128/JVI.01360-19 ABSTRACT It is established that the host cell transcriptomes of natural lesions, organotypic rafts, and human papillomavirus (HPV)-immortalized keratinocytes are altered in the presence of HPV genomes.
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