Dementia is a prevalent disorder leading to substantial healthcare, financial, and caregiver burden (Hurd et al., 2013). Although Alzheimer’s disease is the most common cause of dementia, several coincident pathologies, mainly vascular lesions, limbic TAR-DNA binding protein-43 (TDP-43, encoded by TARDBP) and Lewy body-related pathology, also account for the cognitive symptoms of dementia subjects (Zanetti et al., 2006; Schneider et al., 2007; Toledo et al., 2013a, b, 2016; Wilson et al., 2013).
