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Articles by Rowda Dahir
Over one million potential genome-editing enzymes discovered in microbes
Over one million potential genome-editing enzymes discovered in microbes 20 September 2021 Appeared in BioNews 1113 Researchers looking for evolutionary ancestors of enzymes used in the CRISPR genome editing have uncovered over one million potential genome-editing enzymes. The CRISPR/Cas9 approach uses small pieces of RNA as guides to direct a DNA-cutting enzyme called Cas9 to edit specific locations in the genome.
TALENs outperforms CRISPR/Cas9 in editing compact DNA
TALENs outperforms CRISPR/Cas9 in editing compact DNA 1 February 2021 Appeared in BioNews 1081 Researchers comparing different methods of genome editing have found that in some contexts, TALENs work more efficiently than CRISPR/Cas9. Within the cell, DNA is packaged into a structure known as chromatin, which can be divided into euchromatin and heterochromatin. The former consists of accessible 'open' DNA, and the latter of compact 'closed' DNA.
Safer, targeted method to deliver CRISPR genome therapy developed
Safer, targeted method to deliver CRISPR genome therapy developed 16 November 2020 Appeared in BioNews 1072 Light-activated liposomes may deliver CRISPR gene therapy more safely than current methods, researchers have found. Liposomes are spherical fat structures which resemble cell membranes and can be used to encapsulate and deliver drugs or genes to patients' cells.
CRISPR genome editing improved by enzyme testing
CRISPR genome editing improved by enzyme testing 14 September 2020 Appeared in BioNews 1063 The safety and efficiency of CRISPR genome editing can be improved by identifying the best genome editing option for a specific application. CRISPR is a powerful approach to genome editing where several different enzymes, known as Cas nucleases, are used to edit the genome. However, each of these enzymes vary in characteristics and choosing the right enzyme is crucial.
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