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rula transforms summer concert with unfolding cube At the center of Terence Lam’s White Summer concert at the Hong Kong Coliseum, a seven-meter white cube designed by Ruby Law, founder of RULA Design Studio, rotates, unfolds, and transforms. The structure functions as a sculpture, projection surface, and architectural frame all at once. Conceived as a Pandora’s box, the cube opens and closes to reveal multiple layers of the show’s narrative.
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description cmdc202400360-s1-Supporting_info.pdf1.5 MB Supplementary
Introduction Activation of the single-chain human plasminogen (hPg) following the scission of its Arg561-Val562 bond to produce the two-chain proteolytically active plasmin (hPm) is an essential step in the process leading to the dissolution of the fibrin blood clot (Urano et al., 2018).
In mouse and humans, the H3.3 histone variant is expressed from two distinct genes (H3f3a and H3f3b) which encode identical proteins28,29. The G34R substitution in paediatric gliomas always occur as heterozygous mutations on H3f3a22,23, and tumours retain three normal copies of H3.3 in addition to the canonical H3.1/2 histones. Therefore, the oncogenic properties of H3.3 G34R emerge in a context where the mutant histone comprises a small fraction of total cellular H3.
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