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Articles by Rüdiger Hell
The ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons
Abstract The N-terminal acetyltransferase B (NatB) acetylates ~20% of the eukaryotic proteome. However, the role of NatB-mediated N-terminal acetylation (NTA) for the regulation of the proteome fate remains unclear in eukaryotes. In this study, we demonstrate that CRISPR-Cas9-mediated deletion of NatB activity in plants results in significantly lowered global protein turnover due to decreased ubiquitin-proteasome system (UPS) activity and protein translation.
Novel roles of sulfur metabolism in stress‐controlled stomata aperture regulation
Content Summary 1 I. Introduction 1 II. The role of the cysteine synthase complex in primary sulfur metabolism 3 III. Sulfate acts as a soil-borne signal for stomata closure 3 IV. Cytosolic sulfide controls various stress responses, including stomata closure 6 V. Conclusions and outlook 6 Acknowledgements 6 References 7 I. Introduction Rapid changes in environmental cues force plants to dynamically adapt their metabolism and growth.
Photorespiration is linked to DNA methylation by formate as a one-carbon source - Nature Plants
Abstract Photorespiration is a costly cellular process that reduces photosynthetic efficiency. While mitigating photorespiratory losses could boost crop yields, the interconnection of photorespiration with other processes is increasingly recognized. Its high carbon turnover generates mitochondrial one-carbon (C1) metabolites, including formate, but their contribution to cellular C1 metabolism has remained unclear.
RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α - Nature Communications
Abstract Defective DNA repair and metabolic rewiring are highly intertwined in promoting the development and progression of cancer. However, the molecular players at their interface remain poorly understood. Here we show that an RNF20-HIF1α axis links the DNA damage response and metabolic reprogramming in lung cancer.
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