Abstract Diabetic patients are more likely to develop carotid plaque (CP). However, whether homocysteine (Hcy) levels are associated with plaque occurrence in this population remains unconfirmed. This study aimed to investigate the association between Hcy levels and CP (including single and multiple plaques) in diabetic patients and to explore the mediating role of inflammation. This multicenter cross-sectional study enrolled 5414 diabetic patients from four medical centers.
