1 Introduction Skeletal muscle regeneration is a highly orchestrated process reliant on muscle stem cells (MuSCs), whose fate is governed by complex epigenetic and transcriptional networks.[1-3] Among these regulators, super-enhancers (SEs)—large clusters of transcriptional enhancers with exceptional capacity to drive expression of lineage-defining genes—have emerged as critical epigenetic arbiters of cell identity and tissue regeneration, including in myogenesis.[4, 5] Notably, mechanical...
