1 Introduction Ehlers–Danlos syndrome (EDS) is a rare autosomal connective tissue disorder with hereditary heterogeneity. EDS is currently divided into 13 subtypes based on key characteristics, including joint activity, excessive skin stretching, and tissue fragility. The clinical manifestations of EDS subtypes are different (1, 2). Some subtypes present with skeletal muscle systems and rupture of blood vessels and cavity organs, leading to disability or death in severe cases (3).
