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Abstract Background: Bergapten (BG) is a natural furanocoumarin found in various botanical drugs including Citrus bergamia, Angelica archangelica, and Citrus medica, and it’s a bioactive constituent of Peucedanum guangxiense, an indigenous species in Guangxi, China. Although BG exhibits anti-inflammatory and osteoprotective properties, its effects relevant to periodontitis-mimicking microenvironment remains unexplored.
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