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Articles by Ruoyi Cai
Identity‐By‐Descent Mapping Using Multi‐Individual IBD With Genome‐Wide Multiple Testing Adjustment
Supporting Information Filename Description gepi70015-sup-0001-supmat.docx812.8 KB Figure S1: Estimated decay parameter for genome-wide IBD mapping tests under different algorithm parameters for multi-individual IBD detection.
Identity-by-descent mapping using multi-individual IBD with genome-wide multiple testing adjustment
Abstract We present an identity-by-descent mapping approach to test the association between genome-wide loci and complex traits. Our method evaluates whether levels of genetic similarities at specific genomic locations, captured by local relatedness matrices derived from multi-individual IBD sharing, are associated with phenotypic variation in complex traits.
IBD-based estimation of X chromosome effective population size with application to sex-specific demographic history
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Gene-by-environment interactions influence the fitness cost of gene copy-number variation in yeast
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Estimating the genome-wide mutation rate from thousands of unrelated individuals
We provide a method for estimating the genome-wide mutation rate from sequence data on unrelated individuals by using segments of identity by descent (IBD). The length of an IBD segment indicates the time to shared ancestor of the segment, and mutations that have occurred since the shared ancestor result in discordances between the two IBD haplotypes. Previous methods for IBD-based estimation of mutation rate have required the use of family data for accurate phasing of the genotypes.
IBD-based estimation of X chromosome effective population size with application to sex-specific demographic history
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