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Abstract <i>T. cruzi</i> Phenothiazine derivatives can unselectively inhibit the trypanothione-dependent antioxidant system enzyme trypanothione reductase (TR). A virtual screening of 2163 phenothiazine derivatives from the ZINC15 and PubChem databases docked on the active site of TR showed that 285 compounds have higher affinity than the natural ligand trypanothione disulfide.
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