Ryan Chen
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Articles by Ryan Chen
Electric field–controlled spin transport in a topological insulator interfaced with a ferroelectric antiferromagnet
Reference #1 Abstract INTRODUCTION RESULTS MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES eLetters (0) Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter .
The Critique Illusion: Why Evidence Must Replace Personal Preference in Design Reviews
The Critique Illusion: Why Evidence Must Replace Personal Preference in Design Reviews Stop arguing over aesthetics. Here is how to build a critique culture that drives actual product success. I was sitting in a glass walled conference room, watching a senior product designer present a new checkout flow. The design was the result of three weeks of rigorous user research, behavioral analysis, and iterative testing. The designer walked the stakeholders through the evidence.
California Governor Signs Into Law Bill To Expand Species Take Authorizations For Renewable Energy Projects
On September 20, 2026, Governor Newsom announced the signing of a tranche of bills, including Assembly Bill 550.
Site-specific O-glycans influence lacritin structure and multimerization in tears
1 INTRODUCTION Lacritin is a ~23 kDa glycoprotein at the ocular surface that participates in tear production (Samudre et al., 2011; Sanghi et al., 2001; Wang et al., 2015), antimicrobial activity (McKown et al., 2014; Sharifian Gh et al., 2025), epithelial regeneration (Wang et al., 2006; Wang et al., 2014), and protection against inflammatory stress (Wang et al., 2013).
California Governor Signs into Law Bill to Expand Species Take Authorizations for Renewable Energy Projects
On September 20, 2026, Governor Newsom announced the signing of a tranche of bills, including Assembly Bill 550.
California Legislature Enrolls Bill to Permit the Issuance of Take Authorization for Species Proposed for Listing Under CESA
Assembly Bill 550, enrolled and presented to the governor on September 3, 2026, would amend the California Endangered Species Act (CESA), Fish and Game Code Section 2081(b), to authorize the California Department of Fish and Wildlife (CDFW) to issue incidental take permits (ITPs) covering “species proposed for listing.” Under existing law, a developer cannot obtain an ITP for a species until it is declared a CESA “candidate” species, leaving a regulatory gap during the sometimes lengthy...
California Legislature Enrolls Bill To Permit The Issuance Of Take Authorization For Species Proposed For Listing Under CESA
Allen Matkins Leck Gamble Mallory & Natsis are most popular: within Environment, Finance and Banking, Government and Public Sector topic(s) in United States with readers working within the Technology industries Assembly Bill 550, enrolled and presented to the governor on September 3, 2026, would amend the California Endangered Species Act (CESA), Fish and Game Code Section 2081(b), to authorize the California Department of Fish and Wildlife (CDFW) to issue incidental take permits (ITPs)...
CDFW Issues Comprehensive Additional Guidance for Candidate Bumble Bee Species
On August 3, 2026, the California Department of Fish and Wildlife (CDFW) published Considerations for Conserving Crotch’s Bumble Bee, Franklin’s Bumble Bee, Western Bumble Bee, and Suckley’s Cuckoo Bumble Bee (the “2026 Guidance”) — a 44-page guidance document that substantially expands the agency’s prior June 6, 2023, Survey Considerations for CESA Candidate Bumble Bee Species (the “2023 Survey Guidance”).
CDFW Issues Comprehensive Additional Guidance For Candidate Bumble Bee Species
AM Allen Matkins Leck Gamble Mallory & Natsis More Allen Matkins, founded in 1977, is a California-based law firm with more than 200 attorneys in four major metropolitan areas of California: Los Angeles, Orange County, San Diego, and San Francisco.
Western Spadefoot Toad Granted “Candidate” Species Status Under The California Endangered Species Act
Jennifer Jeffers’s articles from Allen Matkins Leck Gamble Mallory & Natsis are most popular: in United States Allen Matkins Leck Gamble Mallory & Natsis are most popular: within Environment, Government, Public Sector and Energy and Natural Resources topic(s) with readers working within the Technology industries At its August 12-13, 2026 meeting, the California Fish and Game Commission (Commission) unanimously found that a petition to list the western spadefoot toad (Spea hammondii) as...
Commission Further Postpones Western Spadefoot CESA Candidacy Decision To August Meeting
Jennifer Jeffers’s articles from Allen Matkins Leck Gamble Mallory & Natsis are most popular: in United States with readers working within the Retail & Leisure industries Allen Matkins Leck Gamble Mallory & Natsis are most popular: within Environment, Corporate/Commercial Law and Real Estate and Construction topic(s) At its June 18, 2026 meeting, the California Fish and Game Commission (the Commission) voted to further postpone its consideration of whether the Center for Biological...
Commission Further Postpones Western Spadefoot CESA Candidacy Decision to August Meeting
At its June 18, 2026 meeting, the California Fish and Game Commission (the Commission) voted to further postpone its consideration of whether the Center for Biological Diversity’s petition to list the western spadefoot toad (Spea hammondii) may be warranted under the California Endangered Species Act (CESA). The petition seeks to list the northern population as threatened and the southern population as endangered.
Mapping galectin-3 ligands in human tear fluid establishes spliceoform-dependent lacritin binding
Abstract Galectin-3 (Gal-3) is a carbohydrate-binding protein which plays crucial roles in inflammation, immune response, and cell signaling. At the ocular surface, Gal-3 is also known to crosslink transmembrane mucins to support barrier function. However, the biological role of Gal-3 in circulating tear fluid remains largely unexplored. Similarly, whether Gal-3 engages extracellular glycoprotein ligands in tears to affect biological processes is unknown.
Mountain Lion Listed As Threatened Species In Central And Southern California Under The California Endangered Species Act
Jennifer Jeffers’s articles from Allen Matkins Leck Gamble Mallory & Natsis are most popular: in Asia in Asia in Asia Allen Matkins Leck Gamble Mallory & Natsis are most popular: within Environment, Corporate/Commercial Law and Real Estate and Construction topic(s) with readers working within the Aerospace & Defence industries At its February 12, 2026 meeting, the California Fish and Game Commission (the Commission) unanimously voted to list mountain lion (Puma concolor) populations in parts...
Mountain Lion Listed as Threatened Species in Central and Southern California under the California Endangered Species Act
At its February 12, 2026 meeting, the California Fish and Game Commission (the Commission) unanimously voted to list mountain lion (Puma concolor) populations in parts of central and southern California as athreatened species under the California Endangered Species Act (CESA).
Commission Postpones Western Spadefoot Decision to June Meeting
On September 24, 2025, the Center for Biological Diversity submitted a petition (the Petition) to the California Fish and Game Commission (the Commission) to list the western spadefoot toad (Spea hammondii) as threatened throughout its northern population range and endangered throughout its southern population range under the California Endangered Species Act (CESA).
Commission Postpones Western Spadefoot Decision To June Meeting
Allen Matkins Leck Gamble Mallory & Natsis are most popular: within Environment, Corporate/Commercial Law and Real Estate and Construction topic(s) in United States with readers working within the Aerospace & Defence industries On September 24, 2025, the Center for Biological Diversity submitted a petition (the Petition) to the California Fish and Game Commission (the Commission) to list the western spadefoot toad (Spea hammondii) as threatened throughout its northern population range and...
04.07.26 -- Ever Wonder What Running A $50B Capital Facilities Project Feels Like?
EU&PICS Annex 1: CCS short falls after 2 years of implementation This advanced webinar explores Contamination Control Strategies (CCS) to meet EU GMP, PIC/S Annex 1, and ICH Q9(R1) expectations. Learn how to build CCS through three lifecycle stages, perform risk-based assessments using FMECA models, and reduce subjectivity. Real case studies highlight audit readiness, regulatory compliance, and operational improvements across sterile manufacturing, ATMPs, early development, and CDMO environments.
12.11.25 -- Innovation, Growth (And Happiness) Projected For Pharma
E-Book: Powering Digital in Pharma Learn more about Ecolab’s innovative solutions to support the pharmaceutical industry in its digital transformation journey. This comprehensive overview explores digitally enabled strategies that drive operational efficiency, accelerate innovation, and support the pharmaceutical industry’s digital transformation.
Federal Agencies Propose Sweeping Revisions To Endangered Species Act Regulations, Largely Reinstating 2019-2020 Framework
Allen Matkins Leck Gamble Mallory & Natsis are most popular: within Real Estate and Construction topic(s) in United States with readers working within the Retail & Leisure industries On November 19, 2025, the U.S. Fish and Wildlife Service (USFWS) and the National Marine Fisheries Service (NMFS) (collectively, the Services) released four proposed rules that would comprehensively revise key federal Endangered Species Act (ESA) regulations governing listing decisions, critical habitat...
Federal Agencies Propose Sweeping Revisions to Endangered Species Act Regulations, Largely Reinstating 2019–2020 Framework | JD Supra
On November 19, 2025, the U.S. Fish and Wildlife Service (USFWS) and the National Marine Fisheries Service (NMFS) (collectively, the Services) released four proposed rules that would comprehensively revise key federal Endangered Species Act (ESA) regulations governing listing decisions, critical habitat designations, interagency consultation, and “take” protections for threatened species.
Why Manual QbD Leads To Delays, Errors, And Ongoing Frustrations
By Ryan Chen, Product Strategist, ValGenesis Chemistry, Manufacturing, and Controls (CMC) is often seen as a technical checkpoint in drug development—but it’s far more than that. CMC teams are responsible for ensuring consistent quality and compliance across a complex ecosystem of formulation, analytics, manufacturing, and regulatory strategy. Yet many still rely on manual Quality by Design (QbD) processes that introduce delays, errors, and inefficiencies.
A Novel Missense Variant in LMX1A Leads to Autosomal Dominant Nonsyndromic Hearing Loss
1 Introduction Hereditary hearing loss is a heterogeneous entity associated with over 150 known causative genes. It is estimated that ~50% of prelingual hearing loss cases have a genetic factor, and that ~70% of these are cases of non-syndromic hearing loss (NSHL) (Xiao et al. 2023; Schrauwen et al. 2018). Uncovering pathogenic genetic variants is essential to elucidate underlying disease mechanisms and propel effective therapeutic development.
A Novel Missense Variant in LMX1A Leads to Autosomal Dominant Nonsyndromic Hearing Loss
1 Introduction Hereditary hearing loss is a heterogeneous entity associated with over 150 known causative genes. It is estimated that ~50% of prelingual hearing loss cases have a genetic factor, and that ~70% of these are cases of non-syndromic hearing loss (NSHL) (Xiao et al. 2023; Schrauwen et al. 2018). Uncovering pathogenic genetic variants is essential to elucidate underlying disease mechanisms and propel effective therapeutic development.
Commission Grants Six-Month Extension for CDFW’s Burrowing Owl Status Review | JD Supra
At its October 8, 2025, meeting, the California Fish and Game Commission (Commission) granted the California Department of Fish and Wildlife (CDFW) a six-month extension to complete its status review of the March 5, 2024, petition to list the western burrowing owl (BUOW) under the California Endangered Species Act (CESA). The image below details the new BUOW listing timeline.
Commission Grants Quino Checkerspot Butterfly “Candidate” Species Protections Under the California Endangered Species Act | JD Supra
At its August 13-14 meeting, the California Fish and Game Commission (the Commission) unanimously determined that a petition to list the Quino checkerspot butterfly (Euphydryas editha quino) (QCB) as endangered throughout its range in California provides sufficient scientific information to indicate that the petitioned action may be warranted, thereby officially granting the QCB “candidate” species status under the California Endangered Species Act (CESA).
Western Burrowing Owl’s CESA Candidacy Triggers New Compliance Obligations for Developers | JD Supra
On October 10, 2024, the California Fish and Game Commission (Commission) unanimously voted to designate the western burrowing owl (Athene cunicularia hypugaea) as a candidate species under the California Endangered Species Act (CESA), with coverage extending statewide. As a result, the species is now subject to the full protections of CESA during the California Department of Fish and Wildlife’s (CDFW) 12-month status review period.
A heartwarming goodbye
As the years pass, every high school sports team sees its members grow and improve. Many athletes join their sports teams as freshmen and continue playing through their senior year, dedicating hours to practicing and playing with their team. When these athletes reach the last game of their last season, many teams honor their accomplishments they have earned throughout high school with a tradition known as senior night.
California Increases Fines for Unauthorized Water Diversions and Uses | JD Supra
As California prepares for future cycles of water scarcity, the Legislature continues to prioritize enhancing regulations to address critical water supply needs, secure the rights of diverse water holders, and protect essential environmental resources. On September 22, 2024, Governor Newsom signed AB 460 into law, a bill that significantly increases fines for unauthorized water diversions and other violations of state orders related to water use.
Deadbeat Dams Wreak Havoc On Ecosystems Coast-to-Coast
EarthTalk Q&A Dear EarthTalk: What’s the story with so-called “deadbeat dams” causing ecosystem problems across the country? —George H., Seattle, WA The invention of dams was certainly one of humanity’s most innovative feats of engineering. Able to harness power from the water currents, reserving water and effectively controlling floods, dams have been crucial to civilizations since 3,000 B.C. Modern dams are made of concrete and steel, built to withstand tons of water pressure.
The Greenest President Ever? Assessing Biden's Environmental Legacy
EarthTalk Q&A Dear EarthTalk: Now that his time as president is winding down, what will Joe Biden’s environmental legacy look like in the eyes of history? —Maria T., Pittsburgh. PA Joe Biden’s run in the nation’s highest office may be over soon, BUT his environmental legacy will likely be remembered as a pivotal step in American history towards fighting climate change and building a more sustainable future.
California Court of Appeal Clarifies What Constitutes a “Rare” Species Under CEQA | JD Supra
On June 27, 2024, the California First District Court of Appeal affirmed the denial of a writ petition challenging the City of Lafayette’s (City) determination that a 12-unit residential condominium building qualified for the Class 32 infill development exemption under the California Environmental Quality Act (CEQA). (See Nassiri v. City of Lafayette, et al.
Diabetes Mellitus and Gynecological and Inflammation Disorders Increased the Risk of Pregnancy Loss in a Population Study
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Plywood: The Green Building Material Of The Future?
EarthTalk Q&A Dear EarthTalk: Is plywood a viable sustainable material for furniture and home building? –P.K. Plywood is a manufactured composite material consisting of multiple wooden sheets layered on top of one another and glued together. To assess its sustainability, one needs to assess that of its constituent parts, both the wood sheets and the glue in between them.
Commission Grants Extension for Review of Potential Burrowing Owl Protections | JD Supra
As detailed in our previous Legal Alert, six conservation groups filed a petition with the California Fish and Game Commission (Commission) on March 5, 2024 to request the implementation of legal protections for five populations of the western burrowing owl (Athene cunicularia hypugaea) as a threatened or endangered species under the California Endangered Species Act (CESA).
Proposed Rule Offers New Process for Agency Enforcement of Lake or Streambed Alteration Agreements | JD Supra
On May 3, 2024, the California Department of Fish and Wildlife (CDFW or Department) published a Notice of Proposed Action (Proposed Rule) to update its regulations for Lake or Streambed Alteration Agreements (LSAAs). As described in more detail below, the Proposed Rule establishes a new process for CDFW’s suspension and revocation of an LSAA in the case of permittee noncompliance.
California Considers Endangered Species Protection for Burrowing Owls - 2024 Land Use, Environmental & Natural Resources Update | JD Supra
On March 5, 2024, six conservation groups filed a petition with the California Fish and Game Commission (the Commission) to request the implementation of legal protections for five populations of the western burrowing owl (Athene cunicularia hypugaea) under the California Endangered Species Act (CESA).
New State Laws to Facilitate Infrastructure Project Development - 2024 Land Use, Environmental & Natural Resources Update | JD Supra
Two laws enacted in 2023 as part of Governor Gavin Newsom’s infrastructure streamlining package are intended to facilitate development of certain energy, water resources, transportation, semiconductor manufacturing, and other infrastructure projects.
Public Tap Water and Health Risk in Tangerang
Tap water flows to Gwe Nio’s house in Villa Tomang Baru Housing, Tangerang District, with brownish color, mix of sand particles, and earthy smell from September to October 2023. She is not the only one, many residents experience similar problem. This water cloudiness occurs after a prolonged dry season in Indonesia. It is water from the Regional Public Drinking Water Company (PERUMDAM). Many residents complain about this problem, including Gwe Nio.
Case of the month from the Desai Sethi Urology Institute, Florida, USA: bladder outlet obstruction‐induced urinothorax after percutaneous nephrolithotomy
PCNL percutaneous nephrolithotomy PVR postvoid residual urine volume Qmax peak urinary flow rate Introduction Urinothorax, a rare cause of pleural effusion characterised by the presence of urine in the pleural space, typically occurs iatrogenically after urological procedures or spontaneously due to obstructive uropathies.
Give Back Awards
Dr G.W. Williams Secondary School For Ananya, the act of giving back isn’t just personal – she knows it’s a catalyst for fostering a compassionate and supportive community that will thrive for years to come. Ananya is the editor of her school’s newspaper, an executive member of the Changes by Coffee group, and the fundraising coach for her school’s Relay for Life event.
From the cosmos to the high seas: how UW-Madison educators are using game-based learning
University of Wisconsin-Madison educators have designed numerous educational games to aid students in their learning. From an astrophysicist’s journey into the cosmos to learning maritime archaeology through shipwreck investigations, University of Wisconsin-Madison educators have designed numerous educational games to aid students in their learning.
From the cosmos to the high seas: how UW-Madison educators are using game-based learning
University of Wisconsin-Madison educators have designed numerous educational games to aid students in their learning. From an astrophysicist’s journey into the cosmos to learning maritime archaeology through shipwreck investigations, University of Wisconsin-Madison educators have designed numerous educational games to aid students in their learning.
Dissecting Discharges: Recent Ninth Circuit Rulings and EPA Guidelines Interpreting the Clean Water Act | JD Supra
November was an eventful month for the Clean Water Act (CWA). The Ninth Circuit Court of Appeals issued two decisions last month—which will apply to cases and matters in California and other states within the Ninth Circuit—clarifying the types of discharges that are subject to the United States Environmental Protection Agency’s (EPA) CWA Section 402 National Pollutant Discharge Elimination System (NPDES) permitting requirements.
Madison planning for north-south BRT line
City officials have begun planning for a second bus rapid transit (BRT) line running from Madison’s north side through the downtown area to Fitchburg. The City of Madison has begun planning the second bus rapid transit (BRT) line, officials said at a public informational meeting Wednesday. BRT, Madison’s bus-based transit system overhaul, aims to reduce travel time, promote renewable energy and minimize traffic congestion, according to Metro Transit.
Social connectedness and mental health before and during the COVID-19 pandemic in a community sample in Korea
Lee, Sojung, Moon, Hyejoo, Ko, Jisu, Cankaya Sahin, Banu ORCID: https://orcid.org/0000-0003-1882-0528, Caine, Eric and You, Sungeun (2023) Social connectedness and mental health before and during the COVID-19 pandemic in a community sample in Korea. PLoS ONE, 18(10), e0292219. (doi: 10.1371/journal.pone.0292219) (PMID:37856559) (PMCID:PMC10586704) Text 395112.pdf - Published Version Available under License Creative Commons Attribution.
Madison school district to receive nearly 15% drop in general aid for 2023-24 school year
Officials cited increasing property values and a declining student body for the aid reduction. The Madison Metropolitan School District (MMSD) will receive a nearly15% reduction in general state aid for the 2023-24 school year compared to the previous year. According to data released by the Wisconsin Department of Public Instruction (DPI) Friday, MMSD received approximately $37.9 million in general aid for the 2023-24 school year.
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