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Articles by Ryan Kim
Pancreatic injury induces β‐cell regeneration in axolotl
Corresponding Author Jessica L. Whited Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA Correspondence Jessica L. Whited, Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA.
Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryo-electron tomography
Abstract Influenza viruses are enveloped, negative sense single-stranded RNA viruses covered in a dense layer of glycoproteins. Hemagglutinin (HA) accounts for 80-90% of influenza glycoprotein and plays a role in host cell binding and membrane fusion. While previous studies have characterized structures of receptor-free and receptor-bound HA in vitro, the effect of receptor binding on HA organization and structure on virions remains unknown.
An evolutionarily conserved role for VEGF signaling in the expansion of non-vascular tissue during regeneration.
Abstract Salamanders are capable of regenerating whole limbs throughout life, a feat that is unmatched within tetrapods. Limb regeneration is dependent upon the formation of a blastema, which contains undifferentiated cells capable of giving rise to most cells of the regenerated limb. Innervation is required for regeneration, along with many signaling pathways, including FGF, BMP and Wnt, but the role of VEGF signaling during salamander limb regeneration is not well understood.
Putative epithelial-mesenchymal transitions during salamander limb regeneration: Current perspectives and future investigations
CONFLICT OF INTEREST STATEMENT J.L.W. is a cofounder of Matice Biosciences. REFERENCES 1 (2016). The molecular and cellular choreography of appendage regeneration. Cell, 165(7), 1598–1608. https://doi.org/10.1016/j.cell.2016.05.038 2, , & (2015). The axolotl limb blastema: Cellular and molecular mechanisms driving blastema formation and limb regeneration in tetrapods. Regeneration, 2(2), 54–71. https://doi.org/10.1002/reg2.32 3 (2017). Mechanisms of urodele limb regeneration. Regeneration, 4(4), 159–200.
Amputation Triggers Long-Range Epidermal Permeability Changes in Evolutionarily Distant Regenerative Organisms
Abstract Previous studies have reported that amputation invokes body-wide responses in regenerative organisms, but most have not examined the implications of these changes beyond the region of tissue regrowth. Specifically, long-range epidermal responses to amputation are largely uncharacterized, with research on amputation-induced epidermal responses in regenerative organisms traditionally being restricted to the wound site.
An Iridociliochoroidal Myeloid Sarcoma Associated With Relapsed Acute Myeloid Leukemia With FLT3-ITD Mutation, Treated With Gilteritinib, an FLT3 Inhibitor | Genetics and Genomics | JAMA Ophthalmology | JAMA Network
Acute myeloid leukemia (AML) is a malignant condition of poorly differentiated hematopoietic progenitor cells.1 The disease can manifest in the eye with tissue hemorrhage or infiltration and be the presenting sign of systemic disease or evidence of relapse.
Yield, Techniques, and Complications of Transvitreal and Transscleral Biopsies in Small Uveal Melanoma
Question With increasing importance of genetic testing for uveal melanoma, how can we maximize the yield rate for fine-needle aspiration biopsy, especially for small lesions? Findings In this case series, a combined yield rate of 90.9% was achieved for transscleral and transvitreal biopsies of tumors with a median apical height of 2.7 mm.
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