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Articles by Ryan Littich
01.06.26 -- The Unlikely Weapon Against Fentanyl: Your Immune System
ARMR Sciences Inc. has developed a vaccine designed with a novel adjuvant, dmLT, to neutralize fentanyl in the bloodstream before it reaches the central nervous system and binds to μ-opioid receptors (MORs). Tapping Into Nature's Pharmacy To Develop Safer Antiseizure Medications? We caught up with Colleen Carpenter-Swanson, Ph.D., University of Richmond, to discuss the use of zebrafish models to investigate whether vitexin can be used in antiseizure medications.
10.14.25 -- Discovery On Hold: How Shutdowns Stall Science And Shake Trust
Join Drug Discovery Live on October 21 at 1pm ET for a virtual panel discussion on The NAMs Revolution: Smarter, Safer, More Ethical Drug Testing. Registration is free. Carcinogenicity assessments often rely heavily on two-year rodent bioassays. The weight of evidence (WoE) approach seeks to streamline this process, combining thorough science with regulatory practicality.
06.10.25 -- Understanding The Impact Of An RMP On Patient Risks Using Relational Risk Analysis
Using relational risk analysis, let's take a closer look at risk management plans for identifying and managing adverse reactions for administering a new therapy to a patient. Utilizing A Stepwise Approach For Nitrosamine Risk Mitigation The following insights and case studies demonstrate how a tailored, stepwise testing approach can effectively detect, quantify, and control nitrosamine impurities while maintaining cost efficiency.
02.21.25 -- Are Plant-Based APIs The Future Of Pharma And Nutraceuticals?
Unlock the future of advanced therapy medicinal products and antibody-drug conjugates using advanced analytics at the 2025 ISPE Aseptic Conference, taking place March 17-18 in Washington D.C., United States and virtually. Breakout sessions and panel discussions will focus on the following tracks: Advanced Modalities, Advanced Therapy Medicinal Products (ATMPs), Case Studies, Filling Operations, Regulations and Pharma 4.0™, and Sterility and Release. Learn more and register.
12.06.24 -- You Still Can't Find Your Providential CDMO?
Webinar: Demystifying Large Scale Continuous Chromatography for Small Molecules This webinar provides an introduction to developing continuous chromatography using Simulated Moving Bed (SMB) Technology for small molecule applications. Key benefits include rapid development, easy scale-up, cGMP compliance, cost-effectiveness, and sustainability. Attendees will learn the basics of SMB, its advantages over other technologies, and its sustainability benefits. Click here to learn more.
03.05.24 -- Finding New Treatments In Old Therapies
Webinar: PBPK Modeling For Identifying And Mitigating Absorption Risks In Early Drug Development Learn how PBPK modeling can identify potential oral absorption risks and mitigation strategies for early drug candidates and guide early selection of drug form and formulation to achieve clinical study goals. Gain insights into how key drug and formulation factors can impact absorption risks such as poor oral bioavailability, food-drug interactions, and pH-dependent DDI effects.
02.27.24 -- Getting Generic Drugs Right: FDA Revises ANDA Guidance
METTLER TOLEDO's newly updated Track & Trace Guide covers the purpose, technology, and functionality of pharmaceutical track & trace in the manufacturing and production process. Vital reading for anyone involved with track & trace equipment, six chapters discuss industry drivers for track & trace, serialization and aggregation, how track & trace works in the pharmaceutical industry, and how to implement a track & trace program. Learn more here.
12.15.23 -- Which States Are Best To Locate Your Biotech?
How would you go about looking for a modest-sized facility in the U.S. to establish your own development and clinical-stage manufacturing platform? How might a CDMO go about it today? We started this path of inquiry in our previous editorial. Today, the actual tour.
Sulfur Tetrafluoride (SF4) as a Deoxyfluorination Reagent for Organic Synthesis in Continuous Flow Mode
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An active market: Lonza on APIs
EPM speaks to Swiss contract development manufacturing organisation (CDMO) Lonza to learn about the advances taking place across the industry to manufacture high potency active pharmaceutical ingredients (HPAPIs). EPM: What are some of the emerging trends we’re seeing right now in the HPAPI market? RL: We see a direct relationship between the continued validation of precision medicine approaches and the growth of high potency APIs (HPAPIs) in the development pipeline and in regulatory approvals.
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