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Articles by Ryan Solinsky
GLP-1 receptor agonists as pharmacological treatment for obesity after spinal cord injury: clinical considerations
KEYWORDS spinal cord injury GLP-1s glucagon-like peptide-1 receptor agonists dual agonists semaglutide tirzepatide obesity anti-obesity medications List of abbreviations AEs (adverse effects) BMI (body mass index) GIP (gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide) GLP-1 (glucagon-like peptide-1) GLP-1s (glucagon-like peptide-1 receptor agonists and dual agonists) Kcal (kilocalories) SCI (spinal cord injury) Get full text access Log in, subscribe or purchase for...
Perilesional neuromodulation replaces lost sensorimotor function in persons with spinal cord injury
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Abstract Spinal cord injury (SCI) results in permanent impairment of sensory, motor and autonomic function. Epidural electrical stimulation (EES) applied below the lesion can restore voluntary movement, autonomic function and locomotion following chronic SCI. However, impaired sensation below the SCI does not improve during the application of sublesional EES.
By Jonathan Calvert, Samuel Parker, Radu Darie, Elias Shaaya, Ryan Solinsky, Priyanka Miranda, Jaeson Jang, Ekta Tiwari, Sohail Syed, Liza Aguiar, J. Andrew Taylor, Hanlin Tang, Sean McPherson Verified, Ziya L. Gokaslan, Arjun Bansal, Linda Resnik, Thomas Serre, Jared S Fridley, David Borton, Lakshmi N. Govindarajan, Lily M. Del Valle, Raymond M. Villalobos, Wenzhe Xue, Alexios G. Carayannopoulos, Adetokunbo A. Oyelese
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Nature
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Diagnosis and Management of Cardiometabolic Disease After Spinal Cord Injury: Identifying Gaps in Physician Training and Practices
CONTEXT: Cardiometabolic disease (CMD) frequently occurs in individuals with spinal cord injury (SCI), with growing awareness surrounding the expansive scope of this problem. As CMD has significant morbidity and mortality, early guidelines-based screening and management have been established. However, the extent to which these guidelines have been adopted are unclear.
Characterizing preserved autonomic regulation following spinal cord injury: Methods of a novel concerted testing battery and illustrative examples of a new translationally focused data representation
The authors have declared no competing interest. NCT04493372 This study was funded by NIH/NICHD (K23HD102663), with further contributions from the National Center of Neuromodulation for Rehabilitation (P2CHD086844) I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Why do different people with Spinal Cord Injury have differing severity of symptoms with Autonomic Dysreflexia? Exploring relationships of vascular alpha-1 adrenoreceptor and baroreflex sensitivity after SCI
The authors have declared no competing interest. NCT04493372 This study was funded by K23HD102663 (PI: Solinsky) through the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Autonomic impairment is not explained by neurological level of injury or motor-sensory completeness - Spinal Cord
Abstract Cross-sectional study. Determine how well common clinical assessments of level and completeness of injury are correlated with symptoms of autonomic blood pressure instability and secondary medical complications after spinal cord injury (SCI). Academic medical center, United States. Eighty-two individuals with (n = 48) and without (n = 34) SCI had symptoms of autonomic blood pressure instability quantified with the Autonomic Dysfunction Following SCI (ADFSCI) survey.
Patient Perceptions and Clinical Assessments of Cardiometabolic Disease After Subacute Spinal Cord Injury
Abstract To investigate the effectiveness of health care team communication regarding cardiometabolic disease (CMD) risk factors with patients with subacute spinal cord injury (SCI). Multi-site prospective cross-sectional study. Five National Institute on Disability, Independent Living, and Rehabilitation Research Model SCI Rehabilitation Centers.
The Impact of Transcutaneous Spinal Cord Stimulation on Autonomic Regulation after Spinal Cord Injury: A randomized crossover trial
This is a preprint. It has not yet been peer reviewed by a journal. The National Library of Medicine is running a pilot to include preprints that result from research funded by NIH in PMC and PubMed. medRxiv. Display options Format doi: 10.1101/2023.07.18.23292676. Preprint PMID: 37503177 PMCID: PMC10371174 DOI: 10.1101/2023.07.18.23292676 Item in Clipboard Display options Abstract Importance: Individuals with spinal cord injury (SCI) have significant autonomic nervous system dysfunction.
Toward rebalancing blood pressure instability after spinal cord injury with spinal cord electrical stimulation: A mini review and critique of the evolving literature
This paper is only available as a PDF. To read, Please Download here. Abstract High-level spinal cord injury commonly leads to blood pressure instability. This manifests clinically as orthostatic hypotension (OH), where blood pressure can drop to the point of loss of consciousness, and autonomic dysreflexia (AD), where systolic blood pressure can climb to over 300 mmHg in response to an unperceived noxious stimulus.
Onset of the action of intravesical lidocaine after spinal cord injury
ORIGINAL CLINICAL ARTICLE Ryan Solinsky MD Corresponding Author E-mail address: rsolinsky@mgh.harvard.edu http://orcid.org/0000-0002-7121-8678 Division of Spinal Cord Injury Medicine, Spaulding Rehabilitation Hospital, Boston, Massachusetts Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts Spaulding Research Institute, Boston, Massachusetts Correspondence Ryan Solinsky, MD, Spaulding Rehabilitation Hospital, 300 First Avenue, Boston 02129, MA.
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