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Abstract Avoidance behavior is a prominent and impairing feature of anxiety disorders, trauma- and stressor-related disorders, and obsessive-compulsive disorder. A transdiagnostic approach to identifying the neural basis of avoidance is a promising avenue to shed light on the heterogeneity among individuals affected by these conditions, collectively termed anxiety-related disorders (ARDs).
Dear Editor Anxiety-related disorders are extremely common and frequently disabling (1). Current treatments are associated with high drop-out and non-response rates, necessitating new approaches. Transcranial magnetic stimulation (TMS) is now FDA-cleared for anxiety comorbid with major depressive disorder (MDD).
Optimizing repetitive transcranial magnetic stimulation (rTMS) for transdiagnostic neurobehavioral phenotypes necessitates considerations of 1) variations in cortical targeting location and effects on underlying circuitry as well as 2) dosing and effects on therapeutic response.
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