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S-B. Kim

As seen in: Annals of Oncology
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Articles by S-B. Kim

First-line cobimetinib (C) + paclitaxel (P) in patients (pts) with advanced triple-negative breast cancer (TNBC): Updated results and tumoral immune cell infiltration data from the phase 2 COLET study

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By J. A. García-Sáenz, D. W. Miles, S-B. Kim, T. Velu
| Annals of Oncology Verified
Background: Resistance to standard taxane-based chemotherapy is common in TNBC. Preclinical data suggest that MEK inhibition may overcome taxane resistance and enhance antitumor immune response. The safety and efficacy of combining C, a highly selective MEK inhibitor, with P was explored in pts with metastatic/locally advanced TNBC and no prior systemic therapy for metastatic disease. Methods: The COLET study (NCT02322814; EudraCT number, 2014-002230-32) consisted of a safety run-in (n ?
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