The study subjects and clinico-radiological data The study included 50 samples from patients with BCBM who underwent craniotomy and tumor removal at the Chonnam National University Hwasun Hospital between 2004 and 2020. Only 18 out of 50 cases had a matched primary tumor sample. All the specimens were obtained from the archives of Pathology department. Experienced pathologists examined and assessed the selection of the slides and pathological parameters (SSK and KHL).