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To the Editor, Primary and secondary immune thrombocytopenia (ITP) are differentiated by the presence or absence of an underlying driver (lymphoid malignancy, infection, or autoimmune disease), but share a pathophysiology involving platelet glycoprotein-specific antibody-mediated and antibody-independent platelet destruction and inadequate thrombopoiesis [1].
Abstract With a prolonging duration of survivorship, patients with multiple myeloma (MM) who receive high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HCT) have an increased risk of secondary malignancy, most concerning acute leukemia. We retrospectively reviewed the records of all patients with MM who underwent auto-HCT between January 1, 2010, and January 1, 2023, who later developed therapy-related acute leukemia (t-AL).
Abstract The proportion of gastroesophageal junction adenocarcinoma is increasing. This study evaluated trends in early-onset gastric and esophageal cancers and compared socioeconomic and clinical characteristics between early-onset versus late-onset disease. We included all patients with gastric and esophageal cancer from 2004 to 2015 from the National Cancer Database. Patients were categorized by age < 50, 50-69, and ≥ 70 years.
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