1 INTRODUCTION Critically-sized segmental bone defects (CSBDs) resulting from bone metastases resection, traumatic injuries, and severe fractures and infections represent a significant clinical orthopedic challenge.1, 2 CSBDs and complex fractures do not heal spontaneously within a patient's lifetime and therefore require donor-derived or synthetic grafts.3, 4 Although bone autograft is the gold standard of care for bone defects, it is complicated by donor site morbidity, anesthesia time, and...
