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1 Introduction Diabetes mellitus (DM) is a chronic systemic metabolic disorder caused by combination of genetic and environmental factors over an extended period of time (Cole and Florez, 2020). Type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are two major forms of DM, primarily triggered by pancreatic beta cell dysfunction, insulin secretion deficiency and insulin resistance (Eizirik et al., 2020).
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